Treatment of Neurohypophyseal Diabetes Insipidus
نویسندگان
چکیده
منابع مشابه
amilial Neurohypophyseal iabetes Insipidus — An Update ane
Although molecular research has contributed significantly to our knowledge of familial neurohypophyseal diabetes insipidus (FNDI) for more than a decade, the genetic background and the pathogenesis still is not understood fully. Here we provide a review of the genetic basis of FNDI, present recent progress in the understanding of the molecular mechanisms underlying its development, and survey d...
متن کاملA murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons.
Familial neurohypophyseal diabetes insipidus (FNDI) is an autosomal dominant disorder caused by mutations in the arginine vasopressin (AVP) precursor. The pathogenesis of FNDI is proposed to involve mutant protein-induced loss of AVP-producing neurons. We established murine knock-in models of two different naturally occurring human mutations that cause FNDI. A mutation in the AVP signal sequenc...
متن کاملSpontaneous regression of isolated neurohypophyseal langerhans cell histiocytosis with diabetes insipidus.
In pediatric and adolescent patients, the most common causes for a thickened pituitary stalk with central diabetes insipidus are germ cell tumors, lymphocytic infundibuloneurohypophysitis (LIN), and Langerhans cell histiocytosis (LCH). We describe here a 13-year-old girl who had an abrupt onset of polyuria and polydipsia. Magnetic resonance imaging of the brain revealed thickening of the pituit...
متن کاملAutosomal recessive familial neurohypophyseal diabetes insipidus with continued secretion of mutant weakly active vasopressin.
Familial neurohypophyseal diabetes insipidus is an autosomal dominant disorder characterized by post-natal development of arginine vasopressin (AVP) deficiency due to mutations in the AVP gene. All published mutations affect the signal peptide or the neurophysin-II carrier protein and are presumed to interfere with processing of the preprohormone, leading to neuronal damage. We studied an unusu...
متن کاملLack of MRI neurohypophyseal bright signal in a child with congenital nephrogenic diabetes insipidus
1. Rossi AC, Bosco L, Faich GA et al. The importance of adverse reaction reporting by physicians—suprofen and the flank pain syndrome. JAMA 1988; 259: 1203–1204 2. Strom BL, West SL, Sim E et al. The epidemiology of the acute flank pain syndrome from suprofen.Clin Pharmacol Ther 1989; 46: 693–699 3. Wen SF, Parthasarathy R, Iliopulos O et al. Acute renal failure following binge drinking and non...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2013
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2013-2326